Protein Modification Reagents
Cayman Chemical BIotIn-PEG3-azIde 10mg
A PEGylated version of biotin-azide that is more hydrophilic; can be used to label terminal alkynes via copper-catalyzed click reactions or copper-free click reactions with cyclooctynes; used to covalently tag proteins in combination with other tags
Medchemexpress LLC Dbco-PEG3-Glu-VC-PABC-MMAF | 2253947-24-7 | 1743.05 g/mol | C90H127N13O22 | 5 MG
DBCO-PEG3-Glu-VC-PABC-MMAF is a synthetic drug-linker conjugate intended for antibody-drug conjugate research and bioconjugation. It integrates a DBCO click handle, a three-unit PEG spacer, and a Glu-Val-Cit-PABC cathepsin-cleavable linker to deliver the cytotoxic MMAF payload upon intracellular cleavage. Supplied as a solid for use in ADC synthesis workflows.
- Click-chemistry compatible DBCO group enables strain-promoted alkyne-azide cycloaddition (SPAAC).
- Three-unit PEG spacer improves solubility and reduces steric hindrance.
- Glu-Val-Cit-PABC linker is cleavable by cathepsins for intracellular payload release.
- Includes MMAF payload for potent tubulin inhibition after release.
- Provided as a solid suitable for storage and handling in ADC synthesis workflows.
Medchemexpress LLC Pomalidomide-PEG4-COOH | 2138440-81-8 | 98.0% | 521.52 | 250 MG
Pomalidomide-PEG4-COOH is an E3 ligase ligand-linker conjugate used in PROTAC technology. It contains a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.
- E3 ligase ligand-linker conjugate
- Contains Pomalidomide-based cereblon ligand
- Features a 4-unit PEG linker
- Used in PROTAC technology
eMolecules 50586-80-6 | M-PEG3-TOS | AstaTech | MFCD13184964 | 274.330 | C12H18O5S | 95.000 | COCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 402181567
M-PEG3-TOS | AstaTech | 50586-80-6 | MFCD13184964 | 274.330 | C12H18O5S | 95.000 | COCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 402181567
eMolecules 31127-85-2 | Bis-PEG4-acid | Ambeed | MFCD22201545 | 294.300 | C12H22O8 | 97.000 | OC(=O)CCOCCOCCOCCOCCC(O)=O | 25g | 823414862
Bis-PEG4-acid | Ambeed | 31127-85-2 | MFCD22201545 | 294.300 | C12H22O8 | 97.000 | OC(=O)CCOCCOCCOCCOCCC(O)=O | 25g | 823414862
Medchemexpress LLC DBCO-mPEG (MW 5kDa) | 99.1% | 100 MG
DBCO-mPEG (MW 5kDa) is a PEG-based PROTAC linker that plays a crucial role in the synthesis of PROTACs. This compound acts as a click chemistry reagent, incorporating a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups. PROTACs themselves are engineered with two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, allowing for the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains a DBCO group for SPAAC with azide-containing molecules
- Enables selective degradation of target proteins
![eMolecules PC DBCO-PEG3-biotin | BroadpharmMFCD28505553 | 1002.150 | C50H63N7O13S | 98.000 | COc1cc(C(C)OC(=O)NCCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(cc1OCCCC(=O)NCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)[N+]([O-])=O | 10mg | 279709515](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00128114-279709515.PNG-250.jpg)
eMolecules PC DBCO-PEG3-biotin | BroadpharmMFCD28505553 | 1002.150 | C50H63N7O13S | 98.000 | COc1cc(C(C)OC(=O)NCCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(cc1OCCCC(=O)NCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)[N+]([O-])=O | 10mg | 279709515
PC DBCO-PEG3-biotin | BroadpharmMFCD28505553 | 1002.150 | C50H63N7O13S | 98.000 | COc1cc(C(C)OC(=O)NCCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(cc1OCCCC(=O)NCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)[N+]([O-])=O | 10mg | 279709515
Medchemexpress LLC Alkyne-PEG2-iodide | 1234387-33-7 | C7H11IO2 | 100 MG
Alkyne-PEG2-iodide | 1234387-33-7 | C7H11IO2 | 100 MG
Medchemexpress LLC Dbco-(peg2-vc-pab-mmae)2 | 2259318-55-1 | 99.2% | 2835.50 g·mol⁻¹ | C149H224N22O32 | 10 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a click-chemistry compatible ADC linker dimer that carries monomethyl auristatin E (MMAE) payloads on a cleavable Val-Cit-PAB spacer and features a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used for bioconjugation and synthesis of antibody-drug conjugates, enabling controlled intracellular release of MMAE via protease cleavage.
- Enables strain-promoted alkyne-azide cycloaddition for copper-free bioconjugation.
- Includes a Val-Cit-PAB protease-cleavable linker for intracellular payload release.
- Delivers MMAE warheads for potent tubulin inhibition after release.
- Available as a powder with multiple package sizes for research-scale synthesis.
- High supplied purity supports reliable conjugation and analytical characterization.